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KMID : 0974620020200020427
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Bulletin of Dongnam Health University
2002 Volume.20 No. 2 p.427 ~ p.439
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Interaction of Agonist with Nortriptyline on Adrenergic Receptor Binding and Energy Charge
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Jung Ha-Seung
Lee Kook-Sung
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Abstract
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The agonist effect in catecholamine metabolism and energy charge against adrenergic receptor to human platelets was investigated. The binding of nortriptyline was sensitive to the treatment. Human platelets have been shown to possess high affinity binding sites for adrenergic receptor. The binding sites of this receptor have a similar specific affinity for the rat’s brain tissues. In synaptic transmission the catecholamine and adrenergic receptor stimulate the adenylate cyclase activity which reflect the change of energy charge in biological response. In rat medicated with nortriptyline to activate metabolites, the norepinephrine and epinephrine were increased without change in dopamine. adrenergic receptor and its affinity in the nerve membrane system. In administrated with nortriptyline to affect as agonist to activate adrenergic receptor in the rats and the depression patients, the plasma concentrations of circulating norepinephrine and epinephrine were increased without changes of the dopamine. Therefore the nortriptyline treatment as agonist to activate metabolites could be increased the serum levels of norepinephrine and adrenergic receptor but the energy charge was decreased in the rat’s brain and human platelet membranes.
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KEYWORD
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